Human Genome Project
Human Genome Project
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Featured Publications
Wheeler, DA, Srinivasan, M, Egholm, M, Shen, Y, Chen, L, McGuire, A, He, W, Chen, YJ, Makhijani, V et al. The complete genome of an individual by massively parallel DNA sequencing. Nature 2008 Apr 17; 452(7189):872-6. [PubMed]
Muzny, DM, Scherer, SE, Kaul, R, Wang, J, Yu, J, Sudbrak, R, Buhay, CJ, Chen, R, Cree, A et al. The DNA sequence, annotation and analysis of human chromosome 3. Nature 2006 Apr 27; 440(7088):1194-8. [PubMed]
Scherer, SE, Muzny, DM, Buhay, CJ, Chen, R, Cree, A, Ding, Y, Dugan-Rocha, S, Gill, R, Gunaratne, P et al. The finished DNA sequence of human chromosome 12. Nature 2006 Mar 16; 440(7082):346-51. [PubMed]
Ross, MT, Grafham, DV, Coffey, AJ, Scherer, S, McLay, K, Muzny, D, Platzer, M, Howell, GR, Burrows, C et al. The DNA sequence of the human X chromosome. Nature 2005 Mar 17; 434(7031):325-37. [PubMed]
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About the Project
The Human Genome Project (HGP) is an international effort to sequence and annotate the entire estimated 3.3 billion bases of the human genome. The project was conceived in the mid-80s, and it began in 1990. The major contributors for this project include:
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The Genome Institute at Washington University, St. Louis, MO;
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Baylor College of Medicine Human Genome Sequencing Center, Houston, Texas;
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Whitehead Institute for Biomedical Research (MIT), Cambridge, MA;
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DOE, Walnut Creek, CA;
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Wellcome Trust Sanger Institute, Hinxton, England.
The most recent development stemming from HGP is HapMap 3 and Encode 3. Trace data from the HAPMAP Project may be found at TraceArchive for HAPMAP.
The first HGP effort at the BCM-HGSC was completed in 2006, with chromosomes 3, 12 and 30 Mb of X (~10% of the genome). We performed manual annotation and analysis according to Human Annotation Workshop (HAWK) standards, adding hundreds of gene models to those produced by Ensembl analysis. These annotations are available through Vega (see below). Following further analysis the results were published. We used chromosome 12 for our work in the HapMap Project, in expression studies via NimbleGen oligo arrays, and in development of novel genetic analysis tools with Dr. John Belmont. The sequence data and annotations can be viewed with Genboree.
April 14, 2003—International Consortium Completes Human Genome Project
Funding for the Human Genome Project is provided by NIH NHGRI and DOE OBER.
To learn more about the anticipated benefits of the Human Genome Project, go to our information page.
A three-way comparison of mouse and rat to human chromosomes found using Pash is available for browsing.
Our work with chromosomes 3, 12, and X, is described in papers that were recently published in Nature. Please see the citations in the "Publications" section below.
International Genome Consortium Database
Access to the Data
Access to the assembled data can be obtained from the following resources:
NCBI: http://www.ncbi.nlm.nih.gov/genome/guide/human
Ensemble: http://www.ensembl.org/Homo_sapiens
Genboree: http://www.genboree.org
Vega: http://vega.sanger.ac.uk/Homo_sapiens/Info/Index
UCSC: http://genome.ucsc.edu
Citation
All finished data sent to GenBank should be cited according to GenBank's guidelines.
Selected PubMed Citations
Wheeler, DA, Srinivasan, M, Egholm, M, Shen, Y, Chen, L, McGuire, A, He, W, Chen, YJ, Makhijani, V et al. The complete genome of an individual by massively parallel DNA sequencing. Nature 2008 Apr 17; 452(7189):872-6. [PubMed]
Muzny, DM, Scherer, SE, Kaul, R, Wang, J, Yu, J, Sudbrak, R, Buhay, CJ, Chen, R, Cree, A et al. The DNA sequence, annotation and analysis of human chromosome 3. Nature 2006 Apr 27; 440(7088):1194-8. [PubMed]
Scherer, SE, Muzny, DM, Buhay, CJ, Chen, R, Cree, A, Ding, Y, Dugan-Rocha, S, Gill, R, Gunaratne, P et al. The finished DNA sequence of human chromosome 12. Nature 2006 Mar 16; 440(7082):346-51. [PubMed]
Ross, MT, Grafham, DV, Coffey, AJ, Scherer, S, McLay, K, Muzny, D, Platzer, M, Howell, GR, Burrows, C et al. The DNA sequence of the human X chromosome. Nature 2005 Mar 17; 434(7031):325-37. [PubMed]
Lander, ES, Linton, LM, Birren, B, Nusbaum, C, Zody, MC, Baldwin, J, Devon, K, Dewar, K, Doyle, M et al. Initial sequencing and analysis of the human genome. Nature 2001 Feb 15; 409(6822):860-921. [PubMed]