Rat Genome Project
The Brown Rat
Image source: Wikimedia Commons
About the Project
The genome of the Brown Norway rat (Rattus norvegicus) was sequenced by the Rat Genome Sequencing Consortium (RGSC) led by the BCM-HGSC. (1)
This rat is important as a model organism for cardiovascular and psychological research, and has a legacy of decades of study of its physiology in academia and industry.
The BCM-HGSC is currently upgrading the rat genome sequence through various activities. These include finishing BAC clones and selected other regions of the genome, and sequencing of the Y chromosome.
In addition, a new assembly was produced that incorporates sequence from SOLiD data from the Edwin Cuppen's laboratory.
Early funding for the RGSC came from the National Heart, Lung, and Blood Institute (NHLBI) and the National Human Genome Research Institute (NHGRI) and subsequent activities are supported by the NHGRI.
Access to the Data
BLAST searches are available from NCBI
BAC-based Data Resources
Upgrading the Rat Genome White Paper
BAC Resources - Children's Hospital Oakland Research Institute
Selected PubMed Citations
Twigger, SN, Pruitt, KD, Fernandez-Suarez, XM, Karolchik, D, Worley, KC, Maglott, DR, Brown, G, Weinstock, G, Gibbs, RA et al. What everybody should know about the rat genome and its online resources. Nat. Genet. 2008 May; 40(5):523-7. [PubMed]
Worley, KC, Weinstock, GM, Gibbs, RA. Rats in the genomic era. Physiol. Genomics 2008 Feb 19; 32(3):273-82. [PubMed]
(1) Gibbs, RA, Weinstock, GM, Metzker, ML, Muzny, DM, Sodergren, EJ, Scherer, S, Scott, G, Steffen, D, Worley, KC et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 2004 Apr 1; 428(6982):493-521. [PubMed]