Each session will start with a theoretical introduction followed by
practical exercises. The instructors for the course are Suzanne Leal (Baylor College of Medicine)
, Bertram Müller-Myhsok (Max-Planck-Institute of Psychiatry) and
Michael Nothnagel (Max Delbrück Center). Please feel free to bring your
own data sets for discussion and/or analysis.
The course will be held daily from 9:00 AM - 5:00 PM, except on Wednesday when the course will end at
12:30 PM for sightseeing.
MONDAY
July 4, 2005 |
| Morning |
|
Lecture |
| |
|
Basic terminology, introduction to population genetics, calculating lod scores |
| |
|
|
| Afternoon |
|
Lecture |
| |
|
Getting started using UNIX, introduction to linkage analysis, file
system used by the LINKAGE programs, locus types, data entry for a
dominant disease
|
| |
|
Exercises |
| |
|
LINKAGE programs (MLINK, ILINK) |
|
| |
|
TUESDAY
July 5, 2005 |
| Morning |
|
Lecture |
| |
|
Incomplete penetrance, penetrances for autosomal recessive and x-linked inheritence,
allele frequency estimation, loops and detecting genotyping errors
|
| |
|
Exercises |
| |
|
MEGA2, UNKNOWN, PEDMANAGER and PEDCHECK |
| |
|
|
| Afternoon |
|
Lecture |
| |
|
Designing a gene mapping study. Association studies - case
control and family based (trios)
|
| |
|
Exercises |
| |
|
TBA |
|
| |
|
WEDNESDAY
July 6, 2005
|
| Morning |
|
Lecture |
| |
|
Parametric multipoint gene mapping and genetic maps
|
| |
|
Exercises |
| |
|
LINKAGE (LINKMAP), GENEHUNTER and SIMWALK2 |
| |
|
|
| Afternoon |
|
Time for sightseeing |
| |
|
|
|
| |
|
THURSDAY
July 7, 2005
|
| Morning |
|
Lecture |
| |
|
Allele-sharing (nonparametric) methods for both sib-pairs
and extended families
|
| |
|
Exercises |
| |
|
GENEHUNTER and SIMWALK2 |
| |
|
|
| Afternoon |
|
Lecture |
| |
|
Computer tools for fine mapping and gene identification |
| |
|
Exercises |
| |
|
Continued from morning session |
|
| |
|
FRIDAY
July 8, 2005 |
| Morning | |
Lecture |
| |
|
Linkage Admixture |
| | |
Exercises
|
| | |
HOMOG, ANALYZE and GENEHUNTER
|
| | | |
| Afternoon |
|
Lecture |
| | |
Sample size estimation and calculating empirical p-values
|
| |
|
Exercises |
| |
|
SIMULATE, SLINK, MSIM and EpiInfo |
|