About the DGRP

An amazing phenotypic resource: Our collaborator Trudy Mackay has a large set of > 200 inbred D. melanogaster lines with significant amounts of quantitative phenotypic data. These will form the basis of a community wide "Drosophila Genetic Reference Panel" (DGRP) where members of the community can perform phenotypic assays on a pre sequenced set of Drosophila lines for performing association studies at high power. This approach amortizes the sequencing costs over the entire Drosophila community. The figure provides data on three phenotypes, male aggressiveness, ethanol sensitivity and lifespan. The Mackay laboratory also has data on life span, alcohol sensitivity, male aggression, male copulation latency, locomotive behavior, starvation resistance, chill coma recovery, abdominal bristle number, sternal pleural bristle number, adult mRNA transcription levels and olfactory behavior. Additionally many other laboratories have promised to assay hundreds of additional phenotypes once sequence is available.

Data Release

As a service to the community we are releasing all sequence data for this project pre-publication and as soon as possible - often pre-analysis on this ftp site. The data is released here under the standard genome sequence release agreements - please check the readme in the ftp folder. Data will also be deposited into the trace archive and other appropriate depositories.

DGRP line 360 - 12X 454-flx data, 12X Solexa data, aligned sequences for both data sets in fastm format.

Berkeley Drosophila Reference Sequencing Strain ((y[1]; cn[1] bw[1] sp[1]) b) Adams, M. D. et al. The genome sequence of Drosophila melanogaster. Science 287, 2185-95 (2000). - 12X 454-flx data, aligned sequences in fastm format.

DGRP line 375 - 12X 454-long read (500bp) data, aligned sequence in fastm format. (The long read data was generated in house by 454 in Dec 2007 and Jan 2008 prior to the release of their next generation long read platform. We thank 454 Inc. for allowing us to release this data to the public, pre-publication.)