Title | Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Hernandez, RD, Hubisz, MJ, Wheeler, DA, Smith, DG, Ferguson, B, Rogers, J, Nazareth, L, Indap, A, Bourquin, T, McPherson, J, Muzny, DM, Gibbs, RA, Nielsen, R, Bustamante, CD |
Journal | Science |
Volume | 316 |
Issue | 5822 |
Pagination | 240-3 |
Date Published | 2007 Apr 13 |
ISSN | 1095-9203 |
Keywords | Animals, China, Demography, DNA, Mitochondrial, Genetics, Medical, Humans, India, Linkage Disequilibrium, Macaca mulatta, Polymorphism, Single Nucleotide |
Abstract | To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations. |
DOI | 10.1126/science.1140462 |
Alternate Journal | Science |
PubMed ID | 17431170 |
Grant List | 1R01HG003229 / HG / NHGRI NIH HHS / United States NSF0516310 / / PHS HHS / United States RR00163 / RR / NCRR NIH HHS / United States RR015383 / RR / NCRR NIH HHS / United States RR05090 / RR / NCRR NIH HHS / United States |
Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques.
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