Inter and intra-host diversity of RSV in hematopoietic stem cell transplant adults with normal and delayed viral clearance.

TitleInter and intra-host diversity of RSV in hematopoietic stem cell transplant adults with normal and delayed viral clearance.
Publication TypeJournal Article
Year of Publication2024
AuthorsAvadhanula, V, Agustinho, DPaiva, Menon, VKumar, Chemaly, RF, Shah, DP, Qin, X, Surathu, A, Doddapaneni, H, Muzny, DM, Metcalf, GA, Cregeen, SJavornik, Gibbs, RA, Petrosino, JF, Sedlazeck, FJ, Piedra, PA
JournalVirus Evol
Volume10
Issue1
Paginationvead086
Date Published2024
ISSN2057-1577
Abstract

Respiratory syncytial virus (RSV) infection in immunocompromised individuals often leads to prolonged illness, progression to severe lower respiratory tract infection, and even death. How the host immune environment of the hematopoietic stem cell transplant (HCT) adults can affect viral genetic variation during an acute infection is not understood well. In the present study, we performed whole genome sequencing of RSV/A or RSV/B from samples collected longitudinally from HCT adults with normal (
DOI10.1093/ve/vead086
Alternate JournalVirus Evol
PubMed ID38361816
PubMed Central IDPMC10868550