Title | Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Nettleton, JA, Volcik, KA, Demerath, EW, Boerwinkle, E, Folsom, AR |
Journal | Ann Epidemiol |
Volume | 18 |
Issue | 11 |
Pagination | 842-6 |
Date Published | 2008 Nov |
ISSN | 1873-2585 |
Keywords | Aged, Angiopoietin-Like Protein 4, Angiopoietins, Atherosclerosis, Body Mass Index, Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Triglycerides, United States, Weight Gain |
Abstract | PURPOSE: Allelic variation in the adipokine angiopoietin-like 4 gene (ANGPTL4[E40K]) has been cross-sectionally associated with triglycerides, but the effects of genotype, or the interaction between genotype and body weight, on longitudinal triglyceride change have not been studied.METHODS: Body weight, triglycerides, and ANGPTL4[E40K] genotype were determined at baseline (1987-1989) and at 3 follow-up exams (1990-1992, 1993-1995, 1996-1998) in 7,939 white ANGPTL4[E40K] G allele homozygotes and 344 A allele carriers. Changes in body weight and triglycerides were characterized as the difference between exam 4 and baseline measurements.RESULTS: ANGPTL4[E40K] A allele carriers had triglyceride concentrations that were 15 to 18 mg/dL lower than G allele homozygotes at all exams (P<0.0001). Triglycerides increased in both genotype groups over the 9-year period (+19.1+/-0.9 and +16.2+/-4.1 mg/dL in GG and GA/AA, respectively; P difference, 0.48). Weight gain was associated with increased triglycerides to a comparable degree in both genotype groups (+5.5+/-0.3 and +4.3+/-0.9 mg/dL per 2-kg increase in body weight in GG and GA/AA, respectively, p interaction=0.30).CONCLUSIONS: Differences in triglyceride concentrations between ANGPTL4[E40K] A allele carriers and G allele homozygotes are maintained over time, but the degree of increase in triglycerides was similar between groups and was not modified by body weight changes. |
DOI | 10.1016/j.annepidem.2008.07.004 |
Alternate Journal | Ann Epidemiol |
PubMed ID | 18809343 |
PubMed Central ID | PMC2582040 |
Grant List | N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01 HC055019 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States |
Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
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